<tt id="602a2"><acronym id="602a2"></acronym></tt>
<acronym id="602a2"><center id="602a2"></center></acronym>
  Quick Search:       Advanced Search
JIA Yanli,QIU Yan.Antimicrobial mechanism and application prospects in medicine of antimicrobial peptides[J].Journal of Hebei University of Science and Technology,2021,42(1):67-74
Antimicrobial mechanism and application prospects in medicine of antimicrobial peptides
Received:August 10, 2020  Revised:October 28, 2020
中文關鍵詞:  多肽與蛋白質生物化學  抗菌肽  抗菌機制  醫藥應用  抗生素
英文關鍵詞:polypeptide and protein biochemistry  antimicrobial peptides  antimicrobial mechanism  medical application  antibiotics
基金項目:河北省高等學?茖W技術研究項目(ZD2018080); 京津冀三地聯合攻關項目(19YFSLQY00100)
Author NameAffiliationE-mail
JIA Yanli School of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang  
QIU Yan School of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang qiuyan2015@126.com 
Hits: 10013
Download times: 9741
      As the side effects of antibiotics are becoming increasingly prominent and the number of approvals is declining year by year, it is urgent to develop other active substances that are similar in functions and not easy to develop drug resistance. Antimicrobial peptides (AMPs) have broad-spectrum antibacterial activities, thermal stability and unique mechanism of action. They can not only play the role of anti-bacterial infection in vivo and promote apoptosis of cancer cells, but also be used as chemotherapeutic agents against virus and antibacterial materials for hospital settings. In this paper, developments related to antimicrobial mechanisms and activities of antimicrobial peptides against drug-resistant bacteria, anticancer and antiviral infection in the field of medicine are systematically reviewed. The problems of stability, hemolytic and toxicity of antimicrobial peptides are elucidated and the development prospects of AMPs in medicine are provided. Further research on AMPs can be carried out in the following aspects in the future. 1) Antibacterial mechanism in vivo are studied to promote the development and application of antimicrobial peptides;2)Structures of AMPs are optimized by replacing and modifying amino acid residues and hybrid peptides are synthesized to improve their activities, reduce side effects and prevent drug resistance; 3)Application of delivery systems for AMPs or combination of AMPs with green natural extracts is investigated to improve their antibacterial activity and bioavailability.
View Full Text  View/Add Comment  Download reader