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JIA Yanli,QIU Yan.Antimicrobial mechanism and application prospects in medicine of antimicrobial peptides[J].Journal of Hebei University of Science and Technology,2021,42(1):67-74
抗菌肽的抗菌機制及其在醫藥中的應用前景
Antimicrobial mechanism and application prospects in medicine of antimicrobial peptides
Received:August 10, 2020  Revised:October 28, 2020
DOI:10.7535/hbkd.2021yx01009
中文關鍵詞:  多肽與蛋白質生物化學  抗菌肽  抗菌機制  醫藥應用  抗生素
英文關鍵詞:polypeptide and protein biochemistry  antimicrobial peptides  antimicrobial mechanism  medical application  antibiotics
基金項目:河北省高等學?茖W技術研究項目(ZD2018080); 京津冀三地聯合攻關項目(19YFSLQY00100)
Author NameAffiliationE-mail
JIA Yanli School of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang  
QIU Yan School of Biological Science and Engineering, Hebei University of Science and Technology, Shijiazhuang qiuyan2015@126.com 
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中文摘要:
      隨著抗生素副作用的日益凸顯,以及其被批準數量的逐年下降,研發功能相似且不易產生耐藥性的其他活性物質迫在眉睫?咕木哂袕V譜抗菌性、熱穩定性,作用機理獨特,既能起到體內抗病菌感染、促進癌細胞凋亡的作用,還可作為抗病毒化療劑和醫療器械的抗菌材料。系統綜述了抗菌肽的抗菌機制,及其在醫藥領域抑制抗耐藥菌的產生、抗癌以及抗病毒感染的作用,闡明了抗菌肽存在的穩定性、溶血性及毒性等問題,并對其發展前景進行了展望。指出今后可在以下方面對抗菌肽展開深入研究:1)結合體內抑菌機制進行研究,推動抗菌肽的開發應用;2)通過替換、修飾氨基酸殘基,合成雜合肽,優化抗菌肽結構,提高其活性,降低毒副作用并預防耐藥性的產生;3)利用抗菌肽傳遞系統或抗菌肽與綠色天然提取物聯合作用,提高抗菌活性和生物利用度。
英文摘要:
      As the side effects of antibiotics are becoming increasingly prominent and the number of approvals is declining year by year, it is urgent to develop other active substances that are similar in functions and not easy to develop drug resistance. Antimicrobial peptides (AMPs) have broad-spectrum antibacterial activities, thermal stability and unique mechanism of action. They can not only play the role of anti-bacterial infection in vivo and promote apoptosis of cancer cells, but also be used as chemotherapeutic agents against virus and antibacterial materials for hospital settings. In this paper, developments related to antimicrobial mechanisms and activities of antimicrobial peptides against drug-resistant bacteria, anticancer and antiviral infection in the field of medicine are systematically reviewed. The problems of stability, hemolytic and toxicity of antimicrobial peptides are elucidated and the development prospects of AMPs in medicine are provided. Further research on AMPs can be carried out in the following aspects in the future. 1) Antibacterial mechanism in vivo are studied to promote the development and application of antimicrobial peptides;2)Structures of AMPs are optimized by replacing and modifying amino acid residues and hybrid peptides are synthesized to improve their activities, reduce side effects and prevent drug resistance; 3)Application of delivery systems for AMPs or combination of AMPs with green natural extracts is investigated to improve their antibacterial activity and bioavailability.
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